Gene information
Official symbol PRL
Official full name prolactin
Gene type protein-coding gene
Chromosome6p22.3
Gene familyGrowth hormone family; Neuropeptides
Resources
Entrez Gene 5617
HGNC HGNC:9445
Ensembl ENSG00000172179
Vega OTTHUMG00000016111
UCSC uc003ndp.4
GO terms: 37 records
GO Description Category LogP Number of genes Detail
GO:0001936 regulation of endothelial cell proliferation GO Biological Processes -54.5504306 75 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0005179 hormone activity GO Molecular Functions -33.3562443 33 More
GO:0007565 female pregnancy GO Biological Processes -18.4002911 25 More
GO:0007589 body fluid secretion GO Biological Processes -11.5155091 20 More
GO:0007595 lactation GO Biological Processes -4.29648227 9 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0016525 negative regulation of angiogenesis GO Biological Processes -31.9326641 51 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0030879 mammary gland development GO Biological Processes -8.79064244 23 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0031904 endosome lumen GO Cellular Components -9.27147512 9 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0040014 regulation of multicellular organism growth GO Biological Processes -9.11971182 17 More
GO:0044703 multi-organism reproductive process GO Biological Processes -20.5752550 28 More
GO:0044706 multi-multicellular organism process GO Biological Processes -20.0155761 28 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0046425 regulation of receptor signaling pathway via JAK-STAT GO Biological Processes -10.5317026 20 More
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT GO Biological Processes -10.8890337 15 More
GO:0046903 secretion GO Biological Processes -18.5147167 70 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048638 regulation of developmental growth GO Biological Processes -23.5012496 63 More
GO:0048732 gland development GO Biological Processes -26.3979320 74 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050680 negative regulation of epithelial cell proliferation GO Biological Processes -26.5961536 48 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051047 positive regulation of secretion GO Biological Processes -32.2282376 71 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1901343 negative regulation of vasculature development GO Biological Processes -32.5354692 52 More
GO:1902893 regulation of miRNA transcription GO Biological Processes -10.5909336 18 More
GO:1902895 positive regulation of miRNA transcription GO Biological Processes -9.50703189 15 More
GO:1904892 regulation of receptor signaling pathway via STAT GO Biological Processes -12.9980471 24 More
GO:1904894 positive regulation of receptor signaling pathway via STAT GO Biological Processes -11.2917234 16 More
GO:2000181 negative regulation of blood vessel morphogenesis GO Biological Processes -32.6997315 52 More
KEGG pathways: 5 records
KEGG Description Category LogP Number of genes Detail
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04630 JAK-STAT signaling pathway KEGG Pathway -14.4088859 21 More
hsa04917 Prolactin signaling pathway KEGG Pathway -3.17844000 10 More
Drug-Gene interaction
view
Related drugs: 33 records
Drug name Interaction type Source PMID View
alteplase NCI 2482456 view
amitriptyline NCI 67860026621850 view
bacitracin NCI 8194740 view
benznidazole NCI 2129270 view
betamethasone NCI 6548163 view
bupropion NCI 3109881 view
buspirone NCI 2274641 view
carbamazepine NCI 31918953924400 view
cisplatin NCI 2953096 view
clomiphene NCI 6214735 view
clonidine NCI 3663877 view
clozapine NCI 7961556 view
diclofenac NCI 6642786 view
echinacea, unspecified NCI 16194051 view
fluoxymesterone NCI 6161941 view
flurazepam NCI 3081931 view
genistein NCI 7706371 view
gossypol NCI 1233917570758016818716 view
lovastatin NCI 9316617 view
mannitol NCI 8148670 view
melatonin NCI 8977440 view
methylphenidate NCI 91222873035307 view
naloxone NCI 2875176 view
nicardipine NCI 1910948 view
norethindrone NCI 580200 view
phenobarbital NCI 6091795 view
phenothiazine NCI 3918029 view
pilocarpine NCI 6144226 view
promethazine NCI 7228996 view
propylthiouracil NCI 9270719 view
temozolomide NCI 17056093 view
testolactone NCI 3332537 view
zidovudine NCI 9500147 view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
prolactin proteomics inflammation[prognosis (bad)] acute myocardial infarction Reuwer AQ et al. Horm Metab Res. 2011
prolactin proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Al-Kuraishy HM et al. Indian J Endocrinol Metab. 2016
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